PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter.
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ABSTRACT:
SUBMITTER: Lupey-Green LN
PROVIDER: S-EPMC5521201 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter.
Lupey-Green Lena N LN Moquin Stephanie A SA Martin Kayla A KA McDevitt Shane M SM Hulse Michael M Caruso Lisa B LB Pomerantz Richard T RT Miranda Jj L JL Tempera Italo I
Virology 20170426
The Epstein Barr virus (EBV) genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type, and in other herpesviruses, loss of CTCF binding at specific regions correlates with viral reactivation. Here, we demonstrate that binding of PARP1, an important cofactor of CTCF, at the BZLF1 lytic switch promoter restricts EBV reactiv ...[more]
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2023-12-20 | MTBLS7649 | MetaboLights