Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Morales N
PROVIDER: S-EPMC5521747 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
González-Morales Nicanor N Holenka Tristan K TK Schöck Frieder F
PLoS genetics 20170721 7
Many proteins contribute to the contractile properties of muscles, most notably myosin thick filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at the Z-discs that border each sarcomere. In humans, mutations in the actin-binding protein Filamin-C result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic prote ...[more]