Ontology highlight
ABSTRACT:
SUBMITTER: Chung NPY
PROVIDER: S-EPMC5521803 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chung Nancy P Y NPY Ou Xuemei X Khan K M Faisal KMF Salit Jacqueline J Kaner Robert J RJ Crystal Ronald G RG
Cell reports 20170501 6
While highly active anti-retroviral therapy has dramatically improved the survival of HIV-infected individuals, there is an increased risk for other co-morbidities, such as COPD, manifesting as emphysema. Given that emphysema originates around the airways and that human airway basal cells (BCs) are adult airway stem/progenitor cells, we hypothesized that HIV reprograms BCs to a distinct phenotype that contributes to the development of emphysema. Our data indicate that HIV binds to but does not r ...[more]