Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC5522250 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhou Wei W Wang Qi Q Xu Yi Y Jiang Jingting J Guo Jingchun J Yu Huijun H Wei Wenxiang W
Oncotarget 20170601 25
Epithelial-mesenchymal transition (EMT) is a significant risk factor for metastasis in hepatocellular carcinoma (HCC) patients and with poor prognosis. In this study, we demonstrate the key role of RPB5-mediating protein (RMP) in EMT of HCC cells and the mechanism by which RMP promote EMT. RMP increases migration, invasion, and the progress of EMT of HCC cells, which facilitates the accumulation of Snail, a transcriptional repressor involved in EMT initiation. NF-κB is activated by RMP, which di ...[more]