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Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice.


ABSTRACT: Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. The data showed that baicalein remarkably prevented renal dysfunction, ameliorated kidney fibrosis, alleviated epithelial-mesenchymal transition and oxidative stress in hyperuricemia mice. Thus, we concluded that baicalein executed a kidney-protection action in hyperuricemia and therefore may be used as a therapeutic alternative for hyperuricemic nephropathy.

SUBMITTER: Meng X 

PROVIDER: S-EPMC5522264 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice.

Meng Xiaolu X   Mao Zhuo Z   Li Xin X   Zhong Dandan D   Li Min M   Jia Yingli Y   Wei Jing J   Yang Baoxue B   Zhou Hong H  

Oncotarget 20170601 25


Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. The data showed that baicalein remarkably prevented renal dysfunction, ameliorated kidney fibrosis, alleviated epi  ...[more]

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