Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex.
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ABSTRACT:
SUBMITTER: Ahlfeld J
PROVIDER: S-EPMC5522437 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex.
Ahlfeld Julia J Filser Severin S Schmidt Felix F Wefers Annika K AK Merk Daniel J DJ Glaß Rainer R Herms Jochen J Schüller Ulrich U
Scientific reports 20170721 1
We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Interestingly, such Sox2<sup>+</sup> S100<sup>-</sup> cells of the adult cerebellum expanded after adequate physiological stimuli in mice (exercise), and Sox2<sup>+</sup> precursors acquired positivity for the neuronal marker NeuN over time and integrated in ...[more]
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