Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Cortes F
PROVIDER: S-EPMC5522463 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fernandez-Cortes Fernando F Serafim Tiago D TD Wilkes Jonathan M JM Jones Nathaniel G NG Ritchie Ryan R McCulloch Richard R Mottram Jeremy C JC
Scientific reports 20170721 1
Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinome-wide RNAi screen with 176 individual bloodstream form Trypanosoma brucei lines identified PKs required for proliferation in culture. In order to assess which PKs are also potential virulence factors essential in vivo, lines were pooled, inoculated into mice ...[more]