Dataset Information

Implication of the APP Gene in Intellectual Abilities.

ABSTRACT:

Background

Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the activity-regulated cytoskeleton associated protein (ARC) plays an essential role.

Objectives

To examine whether the ARC gene complex may contribute to the genetic components of intellectual function given the crucial role of ARC in brain plasticity and memory formation.

Methods

The ARC complex was tested for association with intelligence (IQ) in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 5,165). As Alzheimer's disease (AD) shares genetics with cognitive functioning, the association was followed up in an AD sample (17,008 cases, 37,154 controls).

Results

The ARC complex revealed association with verbal and total IQ (empirical p = 0.027 and 0.041, respectively) in the ALSPAC. The strongest single variant signal (rs2830077; empirical p = 0.018), within the APP gene, was confirmed in the AD sample (p = 2.76E-03). Functional analyses of this variant showed its preferential binding to the transcription factor CP2.

Discussion

This study implicates APP in childhood IQ. While follow-up studies are needed, this observation could help elucidate the etiology of disorders associated with cognitive dysfunction, such as AD.

SUBMITTER: Myrum C

PROVIDER: S-EPMC5523840 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Implication of the APP Gene in Intellectual Abilities.

Myrum Craig C Nikolaienko Oleksii O Bramham Clive R CR Haavik Jan J Zayats Tetyana T

Journal of Alzheimer's disease : JAD 20170101 2

<h4>Background</h4>Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the activity-regulated cytoskeleton associated protein (ARC) plays an essential role.<h4>Objectives</h4>To examine whether the ARC gene complex may contribute to the genetic components of intellectual function given the crucial role of ARC in brain plasticity and memory formatio ...[more]

PMID: 28671113

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Dataset Information

Implication of the APP Gene in Intellectual Abilities.

Background

Objectives

Methods

Results

Discussion

Publications

Implication of the APP Gene in Intellectual Abilities.

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