Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.

ABSTRACT: Neutrophils are well characterized as mediators of peripheral tissue damage in lupus, but it remains unclear whether they influence loss of self-tolerance in the adaptive immune compartment. Lupus neutrophils produce elevated levels of factors known to fuel autoantibody production, including IL-6 and B cell survival factors, but also reactive oxygen intermediates, which can suppress lymphocyte proliferation. To assess whether neutrophils directly influence the progression of autoreactivity in secondary lymphoid organs (SLOs), we characterized the localization and cell-cell contacts of splenic neutrophils at several stages in the progression of disease in the NZB/W murine model of lupus. Neutrophils accumulate in SLO over the course of lupus progression, preferentially localizing near T lym

SUBMITTER: Bird AK 

PROVIDER: S-EPMC5524201 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature