Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model.
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ABSTRACT:
SUBMITTER: Mehrdana F
PROVIDER: S-EPMC5524353 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model.
Mehrdana Foojan F Kania Per Walter PW Nazemi Sasan S Buchmann Kurt K
PloS one 20170724 7
Excretory/secretory (ES) compounds isolated from third-stage larvae of the anisakid nematode Contracaecum osculatum parasitizing liver of Baltic cod were investigated for effects on immune gene expression in a zebrafish LPS-induced inflammation model. ES products containing a series of proteins, of which some had enzymatic activity, were injected solely or with LPS. ES proteins alone induced up-regulation of a number of immune-related genes, but generally to a lower degree compared to LPS. When ...[more]
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