Ontology highlight
ABSTRACT:
SUBMITTER: Hvorecny KL
PROVIDER: S-EPMC5524515 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hvorecny Kelli L KL Bahl Christopher D CD Kitamura Seiya S Lee Kin Sing Stephen KSS Hammock Bruce D BD Morisseau Christophe C Madden Dean R DR
Structure (London, England : 1993) 20170406 5
Pseudomonas aeruginosa secretes an epoxide hydrolase with catalytic activity that triggers degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and perturbs other host defense networks. Targets of this CFTR inhibitory factor (Cif) are largely unknown, but include an epoxy-fatty acid. In this class of signaling molecules, chirality can be an important determinant of physiological output and potency. Here we explore the active-site chemistry of this two-step α/β-hydrolase ...[more]