Ontology highlight
ABSTRACT:
SUBMITTER: Kim EH
PROVIDER: S-EPMC5524561 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Kim Evelyn H EH Galchev Vladimir I VI Kim Jin Young JY Misek Sean A SA Stevenson Tamara K TK Campbell Matthew D MD Pagani Francis D FD Day Sharlene M SM Johnson T Craig TC Washburn Joseph G JG Vikstrom Karen L KL Michele Daniel E DE Misek David E DE Westfall Margaret V MV
Proteomics. Clinical applications 20160125 5
<h4>Purpose</h4>A goal of this study was to identify and investigate previously unrecognized components of the remodeling process in the progression to heart failure by comparing protein expression in ischemic failing (F) and nonfailing (NF) human hearts.<h4>Experimental design</h4>Protein expression differences were investigated using multidimensional protein identification and validated by Western analysis. This approach detected basal lamina (BL) remodeling, and further studies analyzed sampl ...[more]