Ontology highlight
ABSTRACT:
SUBMITTER: Britton J
PROVIDER: S-EPMC5524626 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Britton Joshua J Meneghini Luz M LM Raston Colin L CL Weiss Gregory A GA
Angewandte Chemie (International ed. in English) 20160805 38
Enzymes catalyze chemical transformations with outstanding stereo- and regio-specificities, but many enzymes are limited by their long reaction times. A general method to accelerate enzymes using pressure waves contained within thin films is described. Each enzyme responds best to specific frequencies of pressure waves, and an acceleration landscape for each protein is reported. A vortex fluidic device introduces pressure waves that drive increased rate constants (kcat ) and enzymatic efficiency ...[more]