Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC5524698 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zhu Yingmin Y Mei Fang F Luo Pei P Cheng Xiaodong X
Scientific reports 20170724 1
Extensive functional studies of the exchange protein directly activated by cAMP (EPAC) family of signaling molecules have demonstrated that EPAC proteins play a fundamental role in several physiological and pathophysiological responses, therefore are attractive drug targets. In this report, the development of a cell-based, medium to high throughput screening assay that is capable of monitoring EPAC-mediated activation of cellular Rap1 in an isoform-specific manner is described. This assay adapts ...[more]