Ontology highlight
ABSTRACT:
SUBMITTER: Chernikov OV
PROVIDER: S-EPMC5524719 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Chernikov Oleg V OV Wong Wei-Ting WT Li Lan-Hui LH Chikalovets Irina V IV Molchanova Valentina I VI Wu Shih-Hsiung SH Liao Jiahn-Haur JH Hua Kuo-Feng KF
Scientific reports 20170724 1
A GalNAc/Gal-specific lectin (CGL) from the edible mussel Crenomytilus grayanus has been demonstrated to exhibit antibacterial properties. However, the mechanism of immune modulation by CGL in mammalian cells remains unclear. Here, we demonstrated that CGL can activate immune responses in macrophages and in mice. In the in vitro cell models, CGL induced tumour necrosis factor-α and interleukin-6 secretion in mouse RAW264.7 macrophages, mouse bone marrow-derived macrophages, human THP-1 macrophag ...[more]