Ontology highlight
ABSTRACT:
SUBMITTER: DeMars KM
PROVIDER: S-EPMC5524742 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in neurology 20170725
Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct size, behavior, and levels of several inflammatory mediators. Results from our double immunofluorescence staining showed JAK3 expression o ...[more]