Dataset Information

Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

ABSTRACT:

Background

Vitamin D deficiency has been linked with dementia risk, cognitive decline, and executive dysfunction. However, the association with memory remains largely unknown.

Objective

To investigate whether low serum 25-hydroxyvitamin D (25(OH)D) concentrations are associated with memory decline.

Methods

We used data on 1,291 participants from the US Cardiovascular Health Study (CHS) and 915 participants from the Dutch Longitudinal Aging Study Amsterdam (LASA) who were dementia-free at baseline, had valid vitamin D measurements, and follow-up memory assessments. The Benton Visual Retention Test (in the CHS) and Rey's Auditory Verbal Learning Test (in the LASA) were used to assess visual and verbal memory, respectively.

Results

In the CHS, those moderately and severely deficient in serum 25(OH)D changed -0.03 SD (95% CI: -0.06 to 0.01) and -0.10 SD (95% CI: -0.19 to -0.02) per year respectively in visual memory compared to those sufficient (p = 0.02). In the LASA, moderate and severe deficiency in serum 25(OH)D was associated with a mean change of 0.01 SD (95% CI: -0.01 to 0.02) and -0.01 SD (95% CI: -0.04 to 0.02) per year respectively in verbal memory compared to sufficiency (p = 0.34).

Conclusions

Our findings suggest an association between severe vitamin D deficiency and visual memory decline but no association with verbal memory decline. They warrant further investigation in prospective studies assessing different memory subtypes.

SUBMITTER: Kuzma E

PROVIDER: S-EPMC5525144 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

Kuźma Elżbieta E Soni Maya M Littlejohns Thomas J TJ Ranson Janice M JM van Schoor Natasja M NM Deeg Dorly J H DJ Comijs Hannie H Chaves Paulo H M PH Kestenbaum Bryan R BR Kuller Lewis H LH Lopez Oscar L OL Becker James T JT Langa Kenneth M KM Henley William E WE Lang Iain A IA Ukoumunne Obioha C OC Llewellyn David J DJ

Journal of Alzheimer's disease : JAD 20160101 4

<h4>Background</h4>Vitamin D deficiency has been linked with dementia risk, cognitive decline, and executive dysfunction. However, the association with memory remains largely unknown.<h4>Objective</h4>To investigate whether low serum 25-hydroxyvitamin D (25(OH)D) concentrations are associated with memory decline.<h4>Methods</h4>We used data on 1,291 participants from the US Cardiovascular Health Study (CHS) and 915 participants from the Dutch Longitudinal Aging Study Amsterdam (LASA) who were de ...[more]

PMID: 26836174

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Dataset Information

Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

Background

Objective

Methods

Results

Conclusions

Publications

Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

Similar Datasets

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