Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature.
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ABSTRACT:
SUBMITTER: Ma XW
PROVIDER: S-EPMC5525648 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature.
Ma Xiao-Wei XW Hao Chang-Ning CN Gu Zhi-Chun ZC Ye Meng M Li Min M Zhang Lan L
Experimental and therapeutic medicine 20170614 2
Patients with acute limb ischemia, deep venous thrombosis and pulmonary artery embolism may be treated with warfarin. The dose-response interaction of warfarin is associated with numerous factors, depending on which an uncommon life-threatening bleeding may occur. The present case study reported on a patient with acute limb ischemia and a history of warfarin-induced bleeding ten years previously and who again developed life threatening bleeding associated with warfarin treatment and received vas ...[more]
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