In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET.
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ABSTRACT:
SUBMITTER: Yusufi N
PROVIDER: S-EPMC5525745 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET.
Yusufi Nahid N Mall Sabine S Bianchi Henrique de Oliveira HO Steiger Katja K Reder Sybille S Klar Richard R Audehm Stefan S Mustafa Mona M Nekolla Stephan S Peschel Christian C Schwaiger Markus M Krackhardt Angela M AM D'Alessandria Calogero C
Theranostics 20170615 9
A number of different technologies have been developed to monitor <i>in vivo</i> the distribution of gene-modified T cells used in immunotherapy. Nevertheless, in-depth characterization of novel approaches with respect to sensitivity and clinical applicability are so far missing. We have previously described a novel method to track engineered human T cells in tumors using <sup>89</sup>Zr-Df-aTCRmu-F(ab')<sub>2</sub> targeting the murinized part of the TCR beta domain (TCRmu) of a transgenic TCR. ...[more]
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