5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus.

ABSTRACT: Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 ?M, and disperse pre-formed biofilms with IC50 values as low as 4.7 ?M. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.

SUBMITTER: Edwards GA 

PROVIDER: S-EPMC5526077 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature