Computational and Experimental Studies of ADP-Ribosylation.
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ABSTRACT:
SUBMITTER: Hammond RG
PROVIDER: S-EPMC5526223 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Computational and Experimental Studies of ADP-Ribosylation.
Hammond Robert G RG Tan Xuan X Chan Matthew M Goel Anupam A Johnson Margaret A MA
Methods in molecular biology (Clifton, N.J.) 20170101
The macrodomains are a multifunctional protein family that function as receptors and enzymes acting on poly(ADP-ribose), ADP-ribosylated proteins, and other metabolites of nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Several new functions for macrodomains, such as nucleic acid binding and protein-protein interaction, have recently been identified in this family. Here, we discuss methods for the identification of new macrodomains in viruses and the prediction of their function. This is fo ...[more]
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