Ontology highlight
ABSTRACT:
SUBMITTER: Fulcher YG
PROVIDER: S-EPMC5526709 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fulcher Yan G YG Prior Stephen H SH Masuko Sayaka S Li Lingyun L Pu Dennis D Zhang Fuming F Linhardt Robert J RJ Van Doren Steven R SR
Structure (London, England : 1993) 20170622 7
Heparan sulfate proteoglycans activate the matrix metalloproteinase-7 zymogen (proMMP-7) and recruit it in order to shed proteins from cell surfaces. This occurs in uterine and mammary epithelia, bacterial killing, lung healing, and tumor cell signaling. Basic tracks on proMMP-7 recognize polyanionic heparin, according to nuclear magnetic resonance and mutations disruptive of maturation. Contacts and proximity measurements guided docking of a heparin octasaccharide to proMMP-7. The reducing end ...[more]