Dataset Information

Kidney Injury and Repair Biomarkers in Marathon Runners.

ABSTRACT:

Background

Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation.

Study design

Prospective observational study.

Setting & participants

Runners participating in the 2015 Hartford Marathon.

Predictor

Completing a marathon.

Outcomes

Acute kidney injury (AKI) as defined by AKI Network (AKIN) criteria. Stage 1 AKI was defined as 1.5- to 2-fold or 0.3-mg/dL increase in serum creatinine level within 48 hours of day 0 and stage 2 was defined as a more than 2- to 3-fold increase in creatinine level. Microscopy score was defined by the number of granular casts and renal tubular epithelial cells.

Measurements

Samples were collected 24 hours premarathon (day 0), immediately postmarathon (day 1), and 24 hours postmarathon (day 2). Measurements of serum creatinine, creatine kinase, and urine albumin were completed, as well as urine microscopy analysis. 6 injury urine biomarkers (IL-6, IL-8, IL-18, kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, and tumor necrosis factor α) and 2 repair urine biomarkers (YKL-40 and monocyte chemoattractant protein 1) were measured.

Results

22 marathon runners were included. Mean age was 44 years and 41% were men. 82% of runners developed an increase in creatinine level equivalent to AKIN-defined AKI stages 1 and 2. 73% had microscopy diagnoses of tubular injury. Serum creatinine, urine albumin, and injury and repair biomarker levels peaked on day 1 and were significantly elevated compared to day 0 and day 2. Serum creatine kinase levels continued to significantly increase from day 0 to day 2.

Limitations

Small sample size and limited clinical data available at all time points.

Conclusions

Marathon runners developed AKI and urine sediment diagnostic of tubular injury. An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon. The results of our study should be validated in larger cohorts with longer follow-up of kidney function.

SUBMITTER: Mansour SG

PROVIDER: S-EPMC5526736 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Kidney Injury and Repair Biomarkers in Marathon Runners.

Mansour Sherry G SG Verma Gagan G Pata Rachel W RW Martin Thomas G TG Perazella Mark A MA Parikh Chirag R CR

American journal of kidney diseases : the official journal of the National Kidney Foundation 20170328 2

<h4>Background</h4>Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation.<h4>Study design</h4>Prospective observational study.<h4>Setting & participants</h4>Runners participating in the 2015 Hartford Marathon.<h4>Predictor</h4>Completing a marathon.<h4>Outcomes</h4>Acute kidney injury (AKI) as defined by AKI Network (AKIN) criteria. Stage 1 AKI was defined as 1.5- to 2-fold or 0.3-mg/dL increase in serum creatinine level within 48 h ...[more]

PMID: 28363731

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Dataset Information

Kidney Injury and Repair Biomarkers in Marathon Runners.

Background

Study design

Setting & participants

Predictor

Outcomes

Measurements

Results

Limitations

Conclusions

Publications

Kidney Injury and Repair Biomarkers in Marathon Runners.

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