Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea.

ABSTRACT:

Background

A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of disputed rpoB mutations in Mycobacterium tuberculosis isolates from South Korea.

Methods

Between August 2009 and December 2015, 130 patients exhibited RIF resistance on the MTBDRplus assay at Asan Medical Center. Among these cases, we identified the strains with disputed rpoB mutation by rpoB sequencing analysis, as well as among the M. tuberculosis strains from the International Tuberculosis Research Center (ITRC).

Results

Among our cases, disputed rpoB mutations led to RIF resistance in at least 6.9% (9/130) of the strains that

SUBMITTER: Jo KW 

PROVIDER: S-EPMC5526954 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature