Ontology highlight
ABSTRACT:
SUBMITTER: Tan AC
PROVIDER: S-EPMC5527529 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Tan Aik Choon AC Jimeno Antonio A Lin Steven H SH Wheelhouse Jenna J Chan Fonda F Solomon Anna A Rajeshkumar N V NV Rubio-Viqueira Belen B Hidalgo Manuel M
Molecular oncology 20090422 5-6
We performed a global methylation profiling assay on 1505 CpG sites across 807 genes to characterize DNA methylation patterns in pancreatic cancer genome. We found 289 CpG sites that were differentially methylated in normal pancreas, pancreatic tumors and cancer cell lines. We identified 23 and 35 candidate genes that are regulated by hypermethylation and hypomethylation in pancreatic cancer, respectively. We also identified candidate methylation markers that alter the expression of genes critic ...[more]