Dataset Information
Unusual Escherichia coli PBP 3 Insertion Sequence Identified from a Collection of Carbapenem-Resistant Enterobacteriaceae Tested In Vitro with a Combination of Ceftazidime-, Ceftaroline-, or Aztreonam-Avibactam.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5527577 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Unusual Escherichia coli PBP 3 Insertion Sequence Identified from a Collection of Carbapenem-Resistant Enterobacteriaceae Tested <i>In Vitro</i> with a Combination of Ceftazidime-, Ceftaroline-, or Aztreonam-Avibactam.
Antimicrobial agents and chemotherapy 20170725 8
Carbapenemase-producing <i>Enterobacteriaceae</i> isolates (<i>n</i> = 110) from health care centers in central Indiana (from 2010 to 2013) were tested for susceptibility to combinations of avibactam (4 μg/ml) with ceftazidime, ceftaroline, or aztreonam. MIC<sub>50</sub>/MIC<sub>90</sub> values were 1/2 μg/ml (ceftazidime-avibactam), 0.5/2 μg/ml (ceftaroline-avibactam), and 0.25/0.5 μg/ml (aztreonam-avibactam.) A β-lactam MIC of 8 μg/ml was reported for the three combinations against one <i>Esch ...[more]