Ontology highlight
ABSTRACT:
SUBMITTER: Kim CK
PROVIDER: S-EPMC5527599 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20170725 8
Studies with methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strain COL have shown that the optimal resistance phenotype requires not only <i>mecA</i> but also a large number of "auxiliary genes" identified by Tn<i>551</i> mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a str ...[more]