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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA.


ABSTRACT: Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.

SUBMITTER: Cienfuegos-Gallet AV 

PROVIDER: S-EPMC5527652 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA.

Cienfuegos-Gallet Astrid V AV   Chen Liang L   Kreiswirth Barry N BN   Jiménez J Natalia JN  

Antimicrobial agents and chemotherapy 20170725 8


Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant <i>Klebsiella pneumoniae</i> in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in <i>mgrB</i> Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb <i>hsdMSR</i> insertion corresponding to IS<i>Kpn25</i>, indicating a clonal expansion of the resistant strain. The insertion region showed 1  ...[more]

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