Chemotherapy-induced Dkk-1 expression by primary human mesenchymal stem cells is p53 dependent.
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ABSTRACT:
SUBMITTER: Hare I
PROVIDER: S-EPMC5527823 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Chemotherapy-induced Dkk-1 expression by primary human mesenchymal stem cells is p53 dependent.
Hare Ian I Evans Rebecca R Fortney James J Moses Blake B Piktel Debbie D Slone William W Gibson Laura F LF
Medical oncology (Northwood, London, England) 20160901 10
Mesenchymal stem cells (MSCs) are abundant throughout the body and regulate signaling within tumor microenvironments. Wnt signaling is an extrinsically regulated pathway that has been shown to regulate tumorigenesis in many types of cancer. After evaluating a panel of Wnt activating and inhibiting molecules, we show that primary human MSCs increase the expression of Dkk-1, an inhibitor of Wnt signaling, into the extracellular environment following chemotherapy exposure in a p53-dependent manner. ...[more]
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