Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Murillo P
PROVIDER: S-EPMC5528178 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Martinez-Murillo Paola P Tran Karen K Guenaga Javier J Lindgren Gustaf G Àdori Monika M Feng Yu Y Phad Ganesh E GE Vázquez Bernat Néstor N Bale Shridhar S Ingale Jidnyasa J Dubrovskaya Viktoriya V O'Dell Sijy S Pramanik Lotta L Spångberg Mats M Corcoran Martin M Loré Karin K Mascola John R JR Wyatt Richard T RT Karlsson Hedestam Gunilla B GB
Immunity 20170501 5
The development of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushered in a new era in HIV-1 vaccination. The recently reported native, flexibly linked (NFL) design allows the generation of native-like trimers from clinical isolates at high yields and homogeneity. As the majority of infections world-wide are of the clade C subtype, we examined responses in non-human primates to well-ordered subtype C 16055 trimers administered in soluble or high-density ...[more]