Ontology highlight
ABSTRACT:
SUBMITTER: Gruber C
PROVIDER: S-EPMC5528447 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Gruber Christina C Koller Ulrich U Murauer Eva M EM Hainzl Stefan S Hüttner Clemens C Kocher Thomas T South Andrew P AP Hintner Helmut H Bauer Johann W JW
Molecular oncology 20130819 6
Targeting tumor marker genes by RNA trans-splicing is a promising means to induce tumor cell-specific death. Using a screening system we designed RNA trans-splicing molecules (RTM) specifically binding the pre-mRNA of SLCO1B3, a marker gene in epidermolysis bullosa associated squamous cell carcinoma (EB-SCC). Specific trans-splicing, results in the fusion of the endogenous target mRNA of SLCO1B3 and the coding sequence of the suicide gene, provided by the RTM. SLCO1B3-specific RTMs containing HS ...[more]