Ontology highlight
ABSTRACT:
SUBMITTER: Mussnich P
PROVIDER: S-EPMC5528467 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Mussnich Paula P D'Angelo Daniela D Leone Vincenza V Croce Carlo Maria CM Fusco Alfredo A
Molecular oncology 20130117 3
The overexpression of the HMGA1 proteins is a feature of human malignant neoplasias and has a causal role in cell transformation. The aim of our study has been to investigate the microRNAs (miRNAs or miRs) regulated by the HMGA1 proteins in the process of cell transformation analyzing the miRNA expression profile of v-ras-Ki oncogene-transformed thyroid cells expressing or not HMGA1 proteins. We demonstrate that, among the miRNAs regulated by cell transformation, there are miR-10b, miR-21, miR-1 ...[more]