Ontology highlight
ABSTRACT:
SUBMITTER: Ma HT
PROVIDER: S-EPMC5528592 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Ma Hoi Tang HT Erdal Sergio S Huang Shan S Poon Randy Y C RY
Molecular oncology 20140602 8
The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. Although a number of small-molecule inhibitors of KIF11 are currently in clinical development, drug-resistance could be developed through compensation by another kinesin called KIF15. Using a newly developed infrared-based cell system, we discovered that the effectiveness of one of the latest generations of KIF11 inhibitor (SB743921) could be enhanced with several inhibitors of Aurora A kinase. Evidence includ ...[more]