Ontology highlight
ABSTRACT:
SUBMITTER: Rytelewski M
PROVIDER: S-EPMC5528603 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Rytelewski Mateusz M Tong Jessica G JG Buensuceso Adrian A Leong Hon S HS Maleki Vareki Saman S Figueredo Rene R Di Cresce Christine C Wu Sherry Y SY Herbrich Shelley M SM Baggerly Keith A KA Romanow Larissa L Shepherd Trevor T Deroo Bonnie J BJ Sood Anil K AK Chambers Ann F AF Vincent Mark M Ferguson Peter J PJ Koropatnick James J
Molecular oncology 20140606 8
Tumor cells have unstable genomes relative to non-tumor cells. Decreased DNA integrity resulting from tumor cell instability is important in generating favorable therapeutic indices, and intact DNA repair mediates resistance to therapy. Targeting DNA repair to promote the action of anti-cancer agents is therefore an attractive therapeutic strategy. BRCA2 is involved in homologous recombination repair. BRCA2 defects increase cancer risk but, paradoxically, cancer patients with BRCA2 mutations hav ...[more]