Senescent stroma promotes prostate cancer progression: the role of miR-210.
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ABSTRACT:
SUBMITTER: Taddei ML
PROVIDER: S-EPMC5528604 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Senescent stroma promotes prostate cancer progression: the role of miR-210.
Taddei Maria Letizia ML Cavallini Lorenzo L Comito Giuseppina G Giannoni Elisa E Folini Marco M Marini Alberto A Gandellini Paolo P Morandi Andrea A Pintus Gianfranco G Raspollini Maria Rosaria MR Zaffaroni Nadia N Chiarugi Paola P
Molecular oncology 20140721 8
We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitat ...[more]
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