Ontology highlight
ABSTRACT:
SUBMITTER: Kotter A
PROVIDER: S-EPMC5528607 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Kötter Annika A Cornils Kerstin K Borgmann Kerstin K Dahm-Daphi Jochen J Petersen Cordula C Dikomey Ekkehard E Mansour Wael Y WY
Molecular oncology 20140701 8
Poly-ADP-ribose-polymerase inhibitors (PARPi) are considered to be optimal tools for specifically enhancing radiosensitivity. This effect has been shown to be replication-dependent and more profound in HR-deficient tumors. Here, we present a new mode of PARPi-mediated radiosensitization which was observed in four out of six HR-proficient tumor cell lines (responders) investigated, but not in normal cells. This effect is replication-independent, as the radiosensitization remained unaffected follo ...[more]