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Drug resistance to targeted therapies: deja vu all over again.


ABSTRACT: A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of resistance to endocrine therapies in breast cancer and those seen with the new generation of targeted cancer therapeutics. Resistance to single-agent cancer therapeutics is frequently the result of reactivation of the signaling pathway, indicating that a major limitation of targeted agents lies in their inability to fully block the cancer-relevant signaling pathway. The development of mechanism-based combinations of targeted therapies together with non-invasive molecular disease monitoring is a logical way forward to delay and ultimately overcome drug resistance development.

SUBMITTER: Groenendijk FH 

PROVIDER: S-EPMC5528618 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Drug resistance to targeted therapies: déjà vu all over again.

Groenendijk Floris H FH   Bernards René R  

Molecular oncology 20140521 6


A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of resistance to endocrine therapies in breast cancer and those seen with the new generation of targeted cancer therapeutics. Resistance to single-agent cancer therapeutics is frequently the result of reactivation of the signaling pathway, indicating that a major limitation of targeted agents lies in their inability to fully block the cancer-relevant sign  ...[more]

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