Ontology highlight
ABSTRACT:
SUBMITTER: Groenendijk FH
PROVIDER: S-EPMC5528618 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Groenendijk Floris H FH Bernards René R
Molecular oncology 20140521 6
A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of resistance to endocrine therapies in breast cancer and those seen with the new generation of targeted cancer therapeutics. Resistance to single-agent cancer therapeutics is frequently the result of reactivation of the signaling pathway, indicating that a major limitation of targeted agents lies in their inability to fully block the cancer-relevant sign ...[more]