Ontology highlight
ABSTRACT:
SUBMITTER: Bigatto V
PROVIDER: S-EPMC5528655 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Bigatto Viola V De Bacco Francesca F Casanova Elena E Reato Gigliola G Lanzetti Letizia L Isella Claudio C Sarotto Ivana I Comoglio Paolo M PM Boccaccio Carla C
Molecular oncology 20140926 2
The inflammatory cytokine Tumor Necrosis Factor Alpha (TNF-α) is known to trigger invasive growth, a physiological property for tissue healing, turning into a hallmark of progression in cancer. However, the invasive response to TNF-α relies on poorly understood molecular mechanisms. We thus investigated whether it involves the MET oncogene, which regulates the invasive growth program by encoding the tyrosine kinase receptor for Hepatocyte Growth Factor (HGF). Here we show that the TNF-α pro-inva ...[more]