Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.
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ABSTRACT:
SUBMITTER: Howitt MR
PROVIDER: S-EPMC5528851 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.
Howitt Michael R MR Lavoie Sydney S Michaud Monia M Blum Arthur M AM Tran Sara V SV Weinstock Joel V JV Gallini Carey Ann CA Redding Kevin K Margolskee Robert F RF Osborne Lisa C LC Artis David D Garrett Wendy S WS
Science (New York, N.Y.) 20160204 6279
The intestinal epithelium forms an essential barrier between a host and its microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans, yet the many ways that gut epithelial cells orchestrate responses to these eukaryotes remain unclear. Here we show that tuft cells, which are taste-chemosensory epithelial cells, accumulate during parasite colonization and infection. Disruption of chemosensory signaling through the loss of TRMP5 abrogates the expansion of t ...[more]
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