Ontology highlight
ABSTRACT:
SUBMITTER: Deretic D
PROVIDER: S-EPMC552909 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Deretic Dusanka D Williams Andrew H AH Ransom Nancy N Morel Valerie V Hargrave Paul A PA Arendt Anatol A
Proceedings of the National Academy of Sciences of the United States of America 20050222 9
The maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the human disease autosomal dominant retinitis pigmentosa. The severe form mutations occur in the C-terminal sorting signal of rhodopsin, VXPX-COOH. Here, we report that this sorting motif binds specifically to the small GTPase ARF4, a member of the ARF family of membrane budding and protein sorting regulators. The effects of blocking ARF4 action were functionally equivalent to the effects of blockin ...[more]