Ontology highlight
ABSTRACT:
SUBMITTER: Jackson HJ
PROVIDER: S-EPMC5529102 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Jackson Hollie J HJ Rafiq Sarwish S Brentjens Renier J RJ
Nature reviews. Clinical oncology 20160322 6
The engineered expression of chimeric antigen receptors (CARs) on the surface of T cells enables the redirection of T-cell specificity. Early clinical trials using CAR T cells for the treatment of patients with cancer showed modest results, but the impressive outcomes of several trials of CD19-targeted CAR T cells in the treatment of patients with B-cell malignancies have generated an increased enthusiasm for this approach. Important lessons have been derived from clinical trials of CD19-specifi ...[more]