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ABSTRACT: Objective
The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study.Methods
Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes followed from shortly after birth. Odds ratios (ORs) were calculated for overweight and obesity by previous intake of energy, protein, carbohydrate, and fat with adjustment for potential confounders.Results
Having overweight or obesity at the age of 5.5 years was positively associated with mean energy intake in previous age intervals (e.g., adjusted OR [95% CI] for overweight: 1.06 [1.04-1.09] per 100 kcal intake at the age of 4.5-5.0 years) and with protein intake after the age of 3.5 and 4.5 years, respectively (e.g., adjusted OR for overweight: 1.06 [1.03-1.09] per 1% of energy intake at the age of 4.5-5.0 years). The respective associations with carbohydrate and fat intake were less consistent.Conclusions
These findings indicate that energy and protein intake are positively associated with increased risk for overweight in childhood but yield no evidence for potential programming effects of protein intake in infancy.
SUBMITTER: Beyerlein A
PROVIDER: S-EPMC5529234 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Beyerlein Andreas A Uusitalo Ulla M UM Virtanen Suvi M SM Vehik Kendra K Yang Jimin J Winkler Christiane C Kersting Mathilde M Koletzko Sibylle S Schatz Desmond D Aronsson Carin Andrén CA Elding Larsson Helena H Krischer Jeffrey P JP Ziegler Anette-G AG Norris Jill M JM Hummel Sandra S
Obesity (Silver Spring, Md.) 20170626 8
<h4>Objective</h4>The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study.<h4>Methods</h4>Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes followed from shortly after birth. Odds ratios (ORs) were calculated for overweight and ...[more]