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Functional RNA structures throughout the Hepatitis C Virus genome.

ABSTRACT: The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics.

SUBMITTER: Adams RL

PROVIDER: S-EPMC5529263 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Functional RNA structures throughout the Hepatitis C Virus genome.

Adams Rebecca L RL Pirakitikulr Nathan N Pyle Anna Marie AM

Current opinion in virology 20170513

The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics. ...[more]

PMID: 28511116

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