Ontology highlight
ABSTRACT:
SUBMITTER: Giagulli C
PROVIDER: S-EPMC5529431 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170726 1
Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the mechanisms responsible for the functional disparity on B cells between a wild-type p17 (refp17) and a vp17 named S75X. Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B- ...[more]