Ontology highlight
ABSTRACT:
SUBMITTER: Guachalla LM
PROVIDER: S-EPMC5529442 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Guachalla Luis M LM Stojkovic Katarina K Hartl Katharina K Kaszowska Marta M Kumar Yadhu Y Wahl Benjamin B Paprotka Tobias T Nagy Eszter E Lukasiewicz Jolanta J Nagy Gábor G Szijártó Valéria V
Scientific reports 20170726 1
Klebsiella pneumoniae is responsible for nosocomial infections causing significant morbidity and mortality. Treatment of newly emerging multi-drug resistant strains is hampered due to severely limited antibiotic choices. Passive immunization targeting LPS O-antigens has been proposed as an alternative therapeutic option, given the limited variability of Klebsiella O-antigens. Here we report that the O3 serogroup, previously considered to have uniform O-antigen built of mannan, represents three d ...[more]