Ontology highlight
ABSTRACT:
SUBMITTER: Aarup A
PROVIDER: S-EPMC5529519 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Aarup Annemarie A Nielsen Carsten H CH Bisgaard Line S LS Bot Ilze I El-Ali Henrik H HH Kjaer Andreas A Nielsen Lars B LB Pedersen Tanja X TX
Scientific reports 20170726 1
Atherosclerotic cardiovascular disease is a major complication of chronic kidney disease (CKD). CKD leads to uremia, which modulates the phenotype of aortic smooth muscle cells (SMCs). Phenotypic modulation of SMCs plays a key role in accelerating atherosclerosis. We investigated the hypothesis that uremia potentiates neointima formation in response to vascular injury in mice. Carotid wire injury was performed on C57BL/6 wt and apolipoprotein E knockout (Apoe <sup>-/-</sup>) mice two weeks after ...[more]