Ontology highlight
ABSTRACT:
SUBMITTER: Jiang R
PROVIDER: S-EPMC5529670 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Jiang Runqiu R Tang Junwei J Chen Yun Y Deng Lei L Ji Jie J Xie Yu Y Wang Ke K Jia Wei W Chu Wen-Ming WM Sun Beicheng B
Nature communications 20170525
Long noncoding RNAs play a pivotal role in T-helper cell development but little is known about their roles in Treg differentiation and functions during the progression of hepatocellular carcinoma (HCC). Here, we show that lnc-epidermal growth factor receptor (EGFR) upregulation in Tregs correlates positively with the tumour size and expression of EGFR/Foxp3, but negatively with IFN-γ expression in patients and xenografted mouse models. Lnc-EGFR stimulates Treg differentiation, suppresses CTL act ...[more]