Ontology highlight
ABSTRACT:
SUBMITTER: Gu J
PROVIDER: S-EPMC5529715 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gu Jiang J Chen Qihan Q Xiao Xiao X Ito Fumiaki F Wolfe Aaron A Chen Xiaojiang S XS
Journal of molecular biology 20160814 23
APOBEC3H (A3H) is the most polymorphic member of the APOBEC3 family. Seven haplotypes (hap I-VII) and four mRNA splicing variants (SV) of A3H have been identified. The various haplotypes differ in anti-HIV activity, which is attributed to differences in protein stability, subcellular distribution, and/or RNA binding and virion packaging. Here, we report the first comparative biochemical studies of all the A3H variants using highly purified proteins. We show that all haplotypes were stably expres ...[more]