Ontology highlight
ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC5530421 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lee Hyunkyoung H Bae Seong Kyeong SK Kim Munki M Pyo Min Jung MJ Kim Minkyung M Yang Sujeoung S Won Chung-Kil CK Yoon Won Duk WD Han Chang Hoon CH Kang Changkeun C Kim Euikyung E
Evidence-based complementary and alternative medicine : eCAM 20170713
Various kinds of animal venoms and their components have been widely studied for potential therapeutic applications. This study evaluated whether <i>Nemopilema nomurai</i> jellyfish venom (NnV) has anticancer activity. NnV strongly induced cytotoxicity of HepG2 cells through apoptotic cell death, as demonstrated by alterations of chromatic morphology, activation of procaspase-3, and an increase in the Bax/Bcl-2 ratio. Furthermore, NnV inhibited the phosphorylation of PI3K, PDK1, Akt, mTOR, p70S6 ...[more]