Unknown

Dataset Information

0

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.


ABSTRACT: OBJECTIVE:Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc-RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc-RA loci through an interdisease meta-genome-wide association (meta-GWAS) strategy. METHODS:The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case-control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. RESULTS:This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P?

SUBMITTER: Lopez-Isac E 

PROVIDER: S-EPMC5530728 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.

López-Isac Elena E   Martín Jose-Ezequiel JE   Assassi Shervin S   Simeón Carmen P CP   Carreira Patricia P   Ortego-Centeno Norberto N   Freire Mayka M   Beltrán Emma E   Narváez Javier J   Alegre-Sancho Juan J JJ   Fernández-Gutiérrez Benjamín B   Balsa Alejandro A   Ortiz Ana M AM   González-Gay Miguel A MA   Beretta Lorenzo L   Santaniello Alessandro A   Bellocchi Chiara C   Lunardi Claudio C   Moroncini Gianluca G   Gabrielli Armando A   Witte Torsten T   Hunzelmann Nicolas N   Distler Jörg H W JH   Riekemasten Gabriella G   van der Helm-van Mil Annette H AH   de Vries-Bouwstra Jeska J   Magro-Checa Cesar C   Voskuyl Alexandre E AE   Vonk Madelon C MC   Molberg Øyvind Ø   Merriman Tony T   Hesselstrand Roger R   Nordin Annika A   Padyukov Leonid L   Herrick Ariane A   Eyre Steve S   Koeleman Bobby P C BP   Denton Christopher P CP   Fonseca Carmen C   Radstake Timothy R D J TR   Worthington Jane J   Mayes Maureen D MD   Martín Javier J  

Arthritis & rheumatology (Hoboken, N.J.) 20160901 9


<h4>Objective</h4>Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc-RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc-RA loci through an interdisease meta-genome-wide association (meta-GWAS) strategy.<h4>Methods</h4>The study was designed as a meta-analysis combining GWAS data sets of patients with SSc  ...[more]

Similar Datasets

| S-EPMC6549285 | biostudies-literature
| S-EPMC6330328 | biostudies-literature
| S-EPMC3033530 | biostudies-literature
| S-EPMC4216016 | biostudies-literature
| S-EPMC7646740 | biostudies-literature
| S-EPMC4285161 | biostudies-literature
| S-EPMC10044038 | biostudies-literature
| S-EPMC5984672 | biostudies-literature
| S-EPMC3114196 | biostudies-literature